diff --git a/Lib/http/cookies.py b/Lib/http/cookies.py
index d0a69cbe1914a0..63d119ad46c084 100644
--- a/Lib/http/cookies.py
+++ b/Lib/http/cookies.py
@@ -335,9 +335,16 @@ def update(self, values):
             key = key.lower()
             if key not in self._reserved:
                 raise CookieError("Invalid attribute %r" % (key,))
+            if _has_control_character(key, val):
+                raise CookieError("Control characters are not allowed in "
+                                  f"cookies {key!r} {val!r}")
             data[key] = val
         dict.update(self, data)
 
+    def __ior__(self, values):
+        self.update(values)
+        return self
+
     def isReservedKey(self, K):
         return K.lower() in self._reserved
 
@@ -363,9 +370,15 @@ def __getstate__(self):
         }
 
     def __setstate__(self, state):
-        self._key = state['key']
-        self._value = state['value']
-        self._coded_value = state['coded_value']
+        key = state['key']
+        value = state['value']
+        coded_value = state['coded_value']
+        if _has_control_character(key, value, coded_value):
+            raise CookieError("Control characters are not allowed in cookies "
+                              f"{key!r} {value!r} {coded_value!r}")
+        self._key = key
+        self._value = value
+        self._coded_value = coded_value
 
     def output(self, attrs=None, header="Set-Cookie:"):
         return "%s %s" % (header, self.OutputString(attrs))
@@ -377,13 +390,16 @@ def __repr__(self):
 
     def js_output(self, attrs=None):
         # Print javascript
+        output_string = self.OutputString(attrs)
+        if _has_control_character(output_string):
+            raise CookieError("Control characters are not allowed in cookies")
         return """
         <script type="text/javascript">
         <!-- begin hiding
         document.cookie = \"%s\";
         // end hiding -->
         </script>
-        """ % (self.OutputString(attrs).replace('"', r'\"'))
+        """ % (output_string.replace('"', r'\"'))
 
     def OutputString(self, attrs=None):
         # Build up our result
diff --git a/Lib/test/test_http_cookies.py b/Lib/test/test_http_cookies.py
index f196bcc48e3792..2478a6c630f5ea 100644
--- a/Lib/test/test_http_cookies.py
+++ b/Lib/test/test_http_cookies.py
@@ -573,6 +573,14 @@ def test_control_characters(self):
             with self.assertRaises(cookies.CookieError):
                 morsel["path"] = c0
 
+            # .__setstate__()
+            with self.assertRaises(cookies.CookieError):
+                morsel.__setstate__({'key': c0, 'value': 'val', 'coded_value': 'coded'})
+            with self.assertRaises(cookies.CookieError):
+                morsel.__setstate__({'key': 'key', 'value': c0, 'coded_value': 'coded'})
+            with self.assertRaises(cookies.CookieError):
+                morsel.__setstate__({'key': 'key', 'value': 'val', 'coded_value': c0})
+
             # .setdefault()
             with self.assertRaises(cookies.CookieError):
                 morsel.setdefault("path", c0)
@@ -587,6 +595,18 @@ def test_control_characters(self):
             with self.assertRaises(cookies.CookieError):
                 morsel.set("path", "val", c0)
 
+            # .update()
+            with self.assertRaises(cookies.CookieError):
+                morsel.update({"path": c0})
+            with self.assertRaises(cookies.CookieError):
+                morsel.update({c0: "val"})
+
+            # .__ior__()
+            with self.assertRaises(cookies.CookieError):
+                morsel |= {"path": c0}
+            with self.assertRaises(cookies.CookieError):
+                morsel |= {c0: "val"}
+
     def test_control_characters_output(self):
         # Tests that even if the internals of Morsel are modified
         # that a call to .output() has control character safeguards.
@@ -607,6 +627,24 @@ def test_control_characters_output(self):
             with self.assertRaises(cookies.CookieError):
                 cookie.output()
 
+        # Tests that .js_output() also has control character safeguards.
+        for c0 in support.control_characters_c0():
+            morsel = cookies.Morsel()
+            morsel.set("key", "value", "coded-value")
+            morsel._key = c0  # Override private variable.
+            cookie = cookies.SimpleCookie()
+            cookie["cookie"] = morsel
+            with self.assertRaises(cookies.CookieError):
+                cookie.js_output()
+
+            morsel = cookies.Morsel()
+            morsel.set("key", "value", "coded-value")
+            morsel._coded_value = c0  # Override private variable.
+            cookie = cookies.SimpleCookie()
+            cookie["cookie"] = morsel
+            with self.assertRaises(cookies.CookieError):
+                cookie.js_output()
+
 
 def load_tests(loader, tests, pattern):
     tests.addTest(doctest.DocTestSuite(cookies))
diff --git a/Misc/NEWS.d/next/Security/2026-03-06-17-03-38.gh-issue-145599.kchwZV.rst b/Misc/NEWS.d/next/Security/2026-03-06-17-03-38.gh-issue-145599.kchwZV.rst
new file mode 100644
index 00000000000000..e53a932d12fcdc
--- /dev/null
+++ b/Misc/NEWS.d/next/Security/2026-03-06-17-03-38.gh-issue-145599.kchwZV.rst
@@ -0,0 +1,4 @@
+Reject control characters in :class:`http.cookies.Morsel`
+:meth:`~http.cookies.Morsel.update` and
+:meth:`~http.cookies.BaseCookie.js_output`.
+This addresses :cve:`2026-3644`.