diff --git a/src/env.ts b/src/env.ts
index 51b51ba9..f396548b 100644
--- a/src/env.ts
+++ b/src/env.ts
@@ -74,10 +74,12 @@ function unenvPreset(opts: CreateEnvOptions) {
     Object.assign(preset.alias, {
       ...Object.fromEntries(
         Object.entries(nodeCompatAliases).flatMap(([from, to]) => {
-          const aliases = [
-            [from, to], // <id> => unenv/node/id
-            [`node:${from}`, to], // node:<id> => unenv/node/id
-          ];
+          const aliases = from.startsWith("node:")
+            ? [[from, to]] // node:<id> => unenv/node/id
+            : [
+                [from, to], // <id> => unenv/node/id
+                [`node:${from}`, to], // node:<id> => unenv/node/id
+              ];
           return aliases;
         }),
       ),
diff --git a/src/preset.ts b/src/preset.ts
index 30b32a5d..0b3cc972 100644
--- a/src/preset.ts
+++ b/src/preset.ts
@@ -67,6 +67,9 @@ export const nodeCompatAliases = {
   wasi: "unenv/node/wasi",
   worker_threads: "unenv/node/worker_threads",
   zlib: "unenv/node/zlib",
+
+  // These only are available via "node:" protocol
+  "node:sqlite": "unenv/node/sqlite",
 } as const;
 
 export const nodeCompatInjects = {
diff --git a/src/runtime/node/sqlite.ts b/src/runtime/node/sqlite.ts
new file mode 100644
index 00000000..f1a872b5
--- /dev/null
+++ b/src/runtime/node/sqlite.ts
@@ -0,0 +1,16 @@
+import type * as nodeSqlite from "node:sqlite";
+import { notImplementedClass } from "../_internal/utils.ts";
+
+export const DatabaseSync: typeof nodeSqlite.DatabaseSync =
+  /*@__PURE__*/ notImplementedClass("sqlite.DatabaseSync");
+
+export const StatementSync: typeof nodeSqlite.StatementSync =
+  /*@__PURE__*/ notImplementedClass("sqlite.StatementSync");
+
+export const constants = {} as typeof nodeSqlite.constants;
+
+export default {
+  DatabaseSync,
+  StatementSync,
+  constants,
+} satisfies typeof nodeSqlite;
diff --git a/test/env.test.ts b/test/env.test.ts
index 0a3ed50c..f363633e 100644
--- a/test/env.test.ts
+++ b/test/env.test.ts
@@ -3,6 +3,8 @@ import { defineEnv } from "../src";
 import { builtinModules } from "node:module";
 import { existsSync } from "node:fs";
 
+const nodeBuiltinModules = ["node:sqlite"];
+
 describe("defineEnv", () => {
   it("defaults", () => {
     const { env } = defineEnv();
@@ -29,6 +31,16 @@ describe("defineEnv", () => {
     }
   });
 
+  it("has aliases for all node: builtin modules", () => {
+    const { env } = defineEnv({ nodeCompat: true });
+    for (const id of builtinModules) {
+      expect(`node:` + env.alias[id]).toBeDefined();
+    }
+    for (const id of nodeBuiltinModules) {
+      expect(env.alias[id]).toBeDefined();
+    }
+  });
+
   it("nagate", () => {
     const { env } = defineEnv({
       nodeCompat: false,